Jane McNeill attended the University of North Carolina at Chapel Hill where she studied Drama and graduated with a BA in Journalism. After 10 years in regional and Chicago theater, she earned a Masters degree in Education at DePaul University. In 2010, after surviving breast cancer, she returned to acting and has spent much of 2011 working on The Walking Dead as the character of Patricia. Subsequent film and television roles have included Prisoners, Rectify, Mississippi Grind, Magic Mike XXL, and Uncle Frank. (오뜨랑에서 실시간으로 번역된 한글 프로필도 확인할 수 있어요) 2021년 드라우트에서 Lorraine 역을 맡았다. 2020년 엉클 프랭크에서 Neva 역을 맡았다. 2019년 Patsy & Loretta에서 Whiskey Soaked Lady 역을 맡았다.