Oyama began performing stand-up comedy at 17 years old. In 2012, she was a state finalist in the Class Clowns competition. That year she also performed at The Sydney Fringe as part of "Barely Legal - Australia's Best Young Comedians" alongside Neel Kolhatkar and Aaron Chen, and performed on Dan Ilic's FBi Radio show. Oyama became a writer for the children's sketch comedy show You're Skitting Me, and made her television debut performing stand-up comedy on SBS 2 in 2014. In 2017, Oyama was cast as executive assistant/receptionist Courtney Kano in the third, fourth, and fifth seasons of Utopia. In the same year, she joined the cast of ABC Comedy's topical entertainment show Tonightly with Tom Ballard as a writer; she also starred in the second and final series of the show in 2018. Oyama directed, co-wrote, and co-starred in The Angus Project, a web series and television pilot that aired on ABC iview in 2018. Based on real events in Bathurst, the series co-stars Angus Thompson as a sports journalist with cerebral palsy, for whom Oyama becomes a friend and caregiver. The show received praise for its earnest depictions of disability and regional Australia. As of 2019 Oyama was regularly performing stand-up comedy. In 2020, she starred on the Network 10 sketch comedy series Kinne Tonight, and served as a scriptwriter for Michael Cusack's Adult Swim series YOLO: Crystal Fantasy. She co-directed the film Diving In, which starred an amputee swimmer and was featured in the 2020 Sydney Film Festival. Also in that year, Oyama received media attention for making "#CatPoop" a trending topic on Twitter in Australia. On 9 July 2024, Deadloch was renewed for a second season and it was announced that Oyama would reprise the role of Abby Matsuda. On 28 October, Oyama was named for the animated film The Pout Pout Fish. On 4 June 2025, Oyama was announced as part of the cast for the series Gnomes. Nina Oyama(1993년생, Bathurst, New South Wales, Australia) 는 배우로, 대표작으로 The Pout-Pout Fish, Soulless, Haven't You Heard? Everyone Hates Me.가 있으며, 그 외에도 Home and Away, Taskmaster Australia, Have You Been Paying Attention?, Spicks and Specks, The Cheap Seats, The Weekly with Charlie Pickering, 데드로크, Guy Montgomery's Guy Mont Spelling Bee, Thank God You're Here, A Bite to Eat with Alice, Shaun Micallef's Origin Odyssey, Question Everything 등 다양한 작품에 출연했다. 특히 2026년에는 The Pout-Pout Fish에도 참여해서 활동중이다. (오뜨랑에서 실시간으로 번역된 한글 프로필도 확인할 수 있어요) 2026년 Class Clowns에 출연했다. 2026년 The Pout-Pout Fish에서 Pip (voice) 역을 맡았다. 2025년 Sunny Nights에서 Sylvie 역을 맡았다.